Personalized medicine for cancer care has become a powerful approach to developing one-of-a-kind treatment plans. In the lab, scientists can now grow miniature tumors from donated tissue, known as patient-derived organoids, which show promise for the future of precision care in pancreatic cancers. During a scientific session presentation at the American Surgical Association’s (ASA) 142nd annual meeting in Chicago, Illinois, The Feinstein Institutes for Medical Research’s Matthew Weiss, MD, shared the results of a new scientific paper on diverse patient-derived organoids. 

The data in the study, done in collaboration with David Tuveson, MD, PhD, and his team of scientists at Cold Spring Harbor Laboratory and with support from the Lustgarten Foundation, stems from the largest single-institution pancreatic cancer patient-derived organoid biobank. It shows the ability to generate organoids from patients, regardless of tumor stage/progression or if the patient had already received chemotherapy. The findings suggest that lab testing of organoids may help predict chemotherapy effectiveness and enable patient-specific therapy plans.

“We are seeing real-time, precision cancer care thanks to significant scientific advancements,” said Dr. Weiss, professor in the Institute of Cancer Research at the Feinstein Institutes and the deputy physician-in-chief and surgical director in the Cancer Institute at Northwell Health. “Presenting this promising data to my colleagues at the ASA is an important step in advancing this research, adding a powerful new tool in our fight against pancreatic cancer.” 

While pancreatic cancer accounts for three percent of all cancers in the United States, it is responsible for seven percent of all cancer deaths. The study collected 136 tumor samples from 117 patients with pancreatic cancer, including 32 percent of organoids derived from minority populations. Organoid generation was seen in more than 70 percent across all tissue samples, regardless of whether the patient had previously received chemotherapy. The organoids were grown in a 3D gel matrix in a small petri-dish, where scientists then studied the tumor's sensitivity to various chemotherapies. 

“Dr. Weiss and collaborators at Cold Spring Harbor Lab are developing new methods to personalize and optimize cancer care,” said Kevin J. Tracey, MD, president and CEO of the Feinstein Institutes. “This important research adds hope to the fight against cancer.”
 
The complete manuscript of this study and its presentation is anticipated to be published in the Annals of Surgery pending editorial review.